The carriers will cooperate through the Worldwide by easyJet partnership allowing connections to Virgin flights at Manchester, Edinburgh and Belfast.
Examples include Jersey to New York and Belfast to Barbados, with some connections available on a daily basis from next summer, such as Belfast to Orlando via Manchester or Edinburgh.
The Belfast connection to Orlando via Manchester involves a two-hour connection outbound and a three hour 20 minute stopover on the inbound journey.
Juha Jarvinen, Virgin chief commercial officer, said: "We’re delighted to be welcoming easyJet customers onboard Virgin Atlantic flights from Manchester, Edinburgh and Belfast.
Sophie Dekkers, easyJet chief commercial officer, added: "We have been delighted with the appetite of partner airlines to expand Worldwide across our network. We remain focussed on offering our unique connections service at more of our biggest airports."