The airline will also operate an additional five aircraft from this winter, taking its fleet from 12 to 17 and capacity to five million passengers each year - a 40% increase in growth.
New destinations of Innsbruck, Lanzarote, Faro, Barcelona and Bordeaux - the 1000th route for the airline will begin November 2 and went on sale today.
EasyJet flew more than 3.5 million passengers from Manchester in 2017 having flown 10 million since the commencing operations in 2008.
The airline said its new aircraft at Manchester would include A320neos, which were introduced to the airport last year.
According to easyJet, the aircraft enable a 15% reduction in fuel burn, a 15% reduction in CO2 emissions and a 50% noise footprint reduction during the landing and take-off compared to the current generation A320s.
As part of the expansion easyJet will also directly create 175 jobs.
Nor is Manchester the only airport to benefit from easyJet route expansion.
Liverpool John Lennon airport will see a new route to Toulouse take off on October 28.
The four-times-weekly service brings the total number of routes on offer at the airport to 32.
