The airline has added Ovda serving Israeli seaside resort Eilat, Grenoble in France, Verona in Italy and Tromso in Norway.
Seats are on sale now, with fares starting from £26.99 one-way.
Owain Jones, Wizz Air chief corporate officer, said: “Our new winter destinations takes our Luton network to 51 destinations in 25 countries.
“The routes will be welcomed by our UK customers looking for an exciting winter break, whether that’s winter sunshine, mountain sports or experiencing some of the finest sights nature has to offer.
“2018 has been a milestone year for Wizz in the UK with the continued expansion of our Luton operations and the launch of Wizz Air UK, the newest British airline.”
Wizz Air says the launch marks the “next phase of growth” in its UK operation, with Wizz Air UK now operating eight Airbus aircraft from Luton.
The launch takes the total number of new Wizz destinations launched this year from Luton to 12 following the additions of Larnaca, Tirana, Tallinn, Bratislava, Lviv, Athens, Keflavik and Bari.
Ovda services will fly Wednesdays and Sundays starting October 28, Greboble and Veronia on Tuesday and Saturdays starting December 15, and Tromso Mondays and Fridays starting December 24.
