The MegaFam – a multi-destination tour – will take place from May 11-18.
To celebrate the fifth consecutive year, the number of agents participating in the 2017 tour will increase from 100 to 107.
They will travel on seven bespoke itineraries to different parts of the US – all meeting for the finale event on May 17.
Two of the groups will fly on British Airways’ new routes to New Orleans, Louisiana and Oakland, California.
To be eligible to win a place on the MegaFam, travel agents in the UK and Ireland must book travellers on American Airlines and British Airways flights to the US during the entry period starting from January 1 through April 3, 2017.
In addition, they must earn a specified number of USA specialist badges on Brand USA’s official agent training site.
Details regarding the number of required bookings and earned specialist badges to secure a place on the 2017 MegaFam will be released by the end of this year.
Brand USA has also announced MegaFams for agents in Canada, Mexico and China will be added to the overall programme, as well as the first coach-based MegaFam for German agents.
This year saw the fourth MegaFam for UK agents. Brand USA has also run four MegaFams for agents from Australia and New Zealand, and two trips from Germany.
During the entry period from January 1 to April 3, 2016, more than 930 agents registered their international flight bookings from the UK and Ireland to the USA, an 87% increase on the previous year.
Brand USA Chief Marketing Officer, Thomas Garzilli, said: “Each year the Brand USA MegaFam sees more and more agents across the UK and Ireland vying to secure a spot, demonstrating both incredible sales skills and consumer demand for the United States.
"We are delighted to be working for a fifth consecutive year with our valued partners at American Airlines and British Airways in developing another exciting set of routes."