The twice-weekly service launches on October 31 with services operating on Tuesdays and Saturdays.
The city will be the seventh Italian destination the airline is serving from the airport with as many as 30,000 passengers a year expected to fly the route.
Liverpool airport air service development director Paul Winfield said: “This latest commitment by easyJet to Liverpool is great news for the airport and for the city region.
“Venice is another new destination to add to the growing list of popular European cities that passengers from across the North West can fly to from Liverpool – the fastest, easiest and friendliest airport in the North West.”
EasyJet country manager Ali Gayward added: “We’re delighted to be adding Venice to easyJet’s destinations from Liverpool. It allows us to further enhance our range of leisure and business destinations from the airport.
“Being one of the most romantic and magical places in the world, Venice often tops peoples list of places to visit at least once in their life.
“It’s also a strong European economic hub and we expect to see plenty of support from the business community on the route.”
Prices for a one-way flight will lead in at £31.99.
