There will be a new service to Birmingham airport as a result and also increased frequencies to East Midlands and Stansted.
The airline expects to fly 300,000 customers a year.
Ryanair’s chief commercial officer, David O’Brien said: "Greece is a significant growth market for Ryanair, and we will continue to connect our Greek airports with Europe’s major cities such as Brussels London and Milan, making Ryanair the ideal choice for business and leisure customers."