Sequeira, who was previously head of marketing and PR for Azamara Club Cruises, takes up her new role on November 6.
Her appointment follows a recent senior restructure at NCL in which Nick Wilkinson was promoted to vice-president and managing director UK & Ireland, the Middle East and Africa.
In the cruise sector, Sequeira has previously worked for Carnival UK, Regent Seven Seas Cruises and Hurtigruten.
She said: “It’s an exciting time to be joining such an innovative business and to support Nick in achieving even greater success in the UK & Ireland and MEA regions.”
Wilkinson added: “2018 is set to be a busy year with the launch of Norwegian Bliss, and with Karen’s experience and in-depth knowledge this will strengthen the brand, and we look forward to the support in our ever-increasing focus in these regions.”
