The pair will also sponsor the main stage at the four-day event which will be known as the Thomas Cook Airlines USA Stage.
It is the sixth consecutive year that the terminal has been a headline sponsor of the LGBT festival and the third occasion for Thomas Cook Airlines.
This year will also mark the second time that either has sponsored the main stage at the event, which is held across the August Bank Holiday.
Manchester airport said supporting the celebration would help focus on new direct flights to San Francisco from Thomas Cook Airlines - which is headquartered at the terminal.
The airline and airport will also have a Pride Parade entry this year plus a space in the event’s Expo, which will be dedicated to talking about the equal opportunities employment roles available at both organisations.
Mark Fletcher, chief executive for Manchester Pride, said: “We have true partners in Thomas Cook Airlines and Manchester airport and couldn’t wish for more committed or supportive sponsors.
“Last year’s activity was a massive success and we can’t wait to see the Thomas Cook Airlines cabin crew connecting with our audience on the Thomas Cook Airlines USA Stage in August.
“I’m looking forward to building on the successful partnership in 2017 as we work together to promote The Big Weekend and the new routes to the USA that Thomas Cook Airlines serve directly from Manchester airport.”
Christoph Debus, chief hotels and airlines officer for Thomas Cook, said: “Last year was such a great party and we want to go even bigger and better this year to celebrate the amazing diversity in our communities and to strengthen the connection we provide between the North West and our seven direct routes to the USA.”
Ken O’Toole, chief executive of Manchester airport, said: "We are pleased to jointly sponsor Manchester Pride’s The Big Weekend, alongside one of our largest airlines, as we prepare to welcome thousands of international visitors to the region over the August Bank Holiday.
"We hope the event will be a great success and wish everyone – staff taking part and members of the public – a great time.”
