The former chief executive of Directline Holidays will remain in the role until the end of April.
A company spokesperson said: “We would like to place on record our thanks to Maria for her contribution to Amadeus and we wish her well for the future.”
Whiteman is well known in the travel industry having occupied a number of senior roles.
She was managing director of luxury long-haul operator Hayes & Jarvis and served in the same position at Travel 2 Travel 4.
Amadeus UK is part of the wider Amadeus IT Group, one of the biggest technology providers in travel and tourism.
Whiteman joined the company in 2013.
