The route will operate every Tuesday from 18 May 2027 to 31 August 2027, supporting Tui's Marella Cruises programme sailing from Palma.
Tui said the early launch would allow customers and agents to secure options for summer 2027 early, with low deposits also available.
A range of Marella sailings will be available from Palma, including itineraries calling in destinations across Spain, as well as in France and Italy, before returning to Palma.
Cruise and stay options are also available, combining a cruise with a seven-night Majorcan beach holiday. The route will also pair with seven- and 14-night beach holidays.
Katrina Barry, Tui's Head of Ireland, said: "We’re delighted to introduce the Cork to Majorca service from Cork for summer 2027, giving Munster holidaymakers even more choice when planning their next sunshine escape.
"Palma is a key port for Marella Cruises, and this route provides fantastic opportunities to explore some of the Mediterranean’s most iconic destinations. Tui are making it easier than ever for customers to secure the holiday that suits them best from their local airport.”
Tara Finn, Head of Aviation Business Development and Communications at Cork airport, added: “Mediterranean cruise holidays remain incredibly popular with Irish consumers and make for fantastic holidays.
"It is wonderful to have the Tui team here in Cork today for this new route announcement flying Cork-Palma in summer 2027. Tui is a valued partner and we’re delighted to see the popular tour operator return to Cork airport for next year’s summer season."