The cancellations impact departures between 12 April and 23 June, with itineraries J205, J206, J207, J208, J209, J210, J211 axed.
P&O said the “current and extraordinary impact” of Covid-19 on the hospitality and travel sectors had caused “temporary disruption” to crew available to join its ships.
“As a result, P&O Cruises will be redeploying crew from Arcadia to other ships in the fleet. This is being done in order to maintain the company’s high standards of service of which we are very proud, across the other five ships in the fleet,” a spokesperson said.
Guests booked on affected cruises will receive a full refund of all monies paid, a future cruise credit and onboard spending to use on a new holiday to booked before 31 December 2023.