The airline will fly to Nantes, Marseille and Valencia, with tickets on sale now, and the first flights will commence from February next year.
Across the new routes the airline is expected to fly 133,000 passengers per year from the airport, operating four times a week to Nantes and Marseille, and three times a week to Valencia.
EasyJet is expected to fly more than six million passengers from the airport this year, an increase of 500,000 in the last 12 months.
Neil Slaven, commercial manager, easyJet, said: “We have seen increasing passenger numbers and demand year-on-year at London Luton airport.
“We will continue to invest and develop Luton as an important London airport for both business and leisure travellers.
“The three new routes on sale today further bolster our summer destination on offer to customers in the region."
Simon Harley, head of business development, London Luton airport, said: “We have invested £110 million into LLA and being able to offer customers more choice in destinations is really important.
“We welcome these three new routes and hope customers who may not have considered LLA will do so this year and next for business or leisure.”
Fares for the new routes start at £28.49 per person.