President and chief executive James Hogan and chief financial officer James Rigney both leave the airline on July 1.
They will be replaced by Ray Gammell as interim group chief executive and Ricky Thirion as interim group financial officer.
However, chairman Mohamed Mubarak Fadhel al-Mazrouei said a permanent group chief executive should be announced in the next few weeks.
The announcement comes as the airline faces up to a number of problems, last week alone Alitalia, which is 49% owned by Etihad, went into administration.
The Gulf airlines have also suffered as lower fuel prices drive down business travel budgets while the terrorist attacks in Europe have depressed the east to west market.
Asian low cost carriers offering direct routes to the heart of Asia are also a threat to future profitability.
