The property will be in the renovated 18th-century Palazzo Salviati Cesi Mellini in central Rome, close to iconic sights such as the Trevi fountain and the Pantheon.
Six Senses Rome will offer 95 rooms and suites, alongside a spa, restaurant, courtyard garden and rooftop terrace with views across the city.
The hotel’s interior design is being overseen by Spanish architect Patricia Urquiola with the ground floor turned into a “social floor for gatherings, meetings, performances and events”.
Six Senses Spa and Roman baths will be housed on the first floor featuring a range of treatment rooms, fitness centre and relaxation areas. There will also be an Earth Lab allowing guests to learn more about sustainability.
Neil Jacobs, Six Senses’ chief executive, said: “As stewards of such a cultural and historical site, we are responsible for celebrating its past and conserving its potential for future generations.
“This is more than a building to me. It is a human project, which is why we are teaming up with the architects and designers who feel as passionate and excited as I do. We want this to be a place of harmony and connection for our guests, sprinkled with a lot of love.”
Six Senses Rome is scheduled to open in late 2021.