The US carrier, which is a joint business partner of British Airways, operates out of Heathrow in the UK, and Dublin in Ireland.
Daily Heathrow services to Dallas Fort Worth, New York JFK and Chicago O’Hare International are already under way, as is American’s three-times-weekly Heathrow-Charlotte service.
Its daily Heathrow-Miami International service is pencilled in to restart on 27 March, followed by Los Angeles and Philadelphia International on 28 March.
A new three-times-weekly Heathrow-Seattle service, meanwhile, is scheduled to start on 30 March, operated by a Boeing 777-200 aircraft. It will increase to a daily service from 3 June.
Elsewhere, American’s daily Dublin-Philadelphia service will restart on 28 March.
“We will be here for when our customers are ready to fly,” said Tom Lattig, American’s vice-president EMEA – sales.
Lattig added American had taken "extensive steps" to ensure safety, including pursuing STAR certification from the Global Biorisk Advisory Council for its entire fleet and its Admirals Club lounges.
Like BA, American is trialling digital health passport VeriFLY, which allows passengers to certify any necessary Covid travel documentation.
